Thompson Rivers University

Heidi Huttunen-Hennelly

Name: Dr. Heidi Huttunen-Hennelly
Position: Associate Professor
Phone: 1-250-377-6063


Spending time with family and friends, watching WolfPack varsity games, sports, traveling, and gardening.

Research Interests

Using the de novo approach to design antimicrobial peptides (AMPs)

Studying AMP structure-activity relationships

Developing novel methods to investigate AMP mechanism of action


BSc (University of British Columbia, 2000)
PhD (University of British Columbia, 2006)


Matheson, S.; Cheeptham, N.; Huttunen-Hennelly, H.E.K. Investigating the Effects of Hydrophobicity and Charge on the Therapeutic Ability of the Antimicrobial Histatin 8 Peptide for Potential Use in Oral Applications, International Journal of Biology. 2013, 5, 85-91.

Azad, M.A.; Huttunen-Hennelly, H.E.K.; Ross Friedman, C. Bioactivity and the First TEM Immunogold Studies of Short de novo Designed Antimicrobial Peptides, Antimicrob. Agents Ch. 2011, 55, 2137-2145.

Jones, D.S.A.; Huttunen-Hennelly, H.E.K.; Donkor, K.K. The Design and Synthesis of Alanine-Based Indolicidin Derivatives with Identical Physiochemical Properties, and their Separation Using Capillary Electrophoresis, Anal. Bioanal. Chem. 2010, 398, 3073-3079.

Podorieszach, A.P.; Huttunen-Hennelly, H.E.K. The Effects of Tryptophan and Hydrophobicity on the Structure and Bioactivity of Novel Indolicidin Derivatives with Promising Pharmaceutical Potential, Org. Biomol. Chem. 2010, 8, 1679-1687.

Huttunen-Hennelly, H.E.K. An Investigation into the N- and C-Capping Effects of Glycine in Cavitand-Based Four-Helix Bundle Proteins, Bioorg. Chem. 2010, 38, 98-107.

Huttunen-Hennelly, H.E.K.; Sherman, J.C. An Investigation into the Native-Like Properties of De Novo Designed Cavitand-Based Four-Helix Bundle Proteins, Pept. Sci. 2008, 1, 37-50.

Huttunen-Hennelly, H.E.K.; Sherman, J.C. The Design, Synthesis, and Characterization of the First Cavitand-Based De Novo Hetero-Template-Assembled Synthetic Proteins (Hetero-TASPs), Org. Biomol. Chem. 2007, 5, 3637-3650.

Scott, W.R.P.; Seo, E.; Huttunen, H.; Wallhorn, D.; Sherman, J.C.; Straus, S.K. Characterization of de Novo Four-Helix Bundles by Molecular Dynamics Simulations, Proteins: Struc. Func. Bioinfor. 2006, 64, 719-729.

Courses Taught

Chem 120 (Fundaments of Chemistry 2)
Chem 121 (Principles of Chemistry 2)
Chem 121/125L (Principles of Chemistry Lab)
Chem 1500 (Chemical Bonding and Organic Chemistry)
Chem 2120 (Organic Chemistry 1)
Chem 2220 (Organic Chemistry 2)
Chem 2250 (Fundamentals of Physical Chemistry)
Chem 2250L (Fundamentals of Physical Chemistry Lab)
Chem 3220 (Advanced Organic Chemistry)
Chem 3230 (Organic Spectroscopy)
Chem 3240 (Organic Chemistry Laboratory)
Chem 4450 (Advanced Chemical Biology Lab)


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